Tramadol And CBD Oil Interaction In Dogs

Why Vets Choose Tramadol for Dogs What does Tramadol do for pain in dogs? How Tramadol Works Side Effects of Tramadol for Dogs Concerns about Tramadol for Dogs Alternatives to Tramadol for Dogs Pain treatment is an unfortunate reality many dog owners must face at some point. It's sad, but it's also scary. If your dog i Can CBD interact with tramadol, an opioid analgesic? Learn more about the mechanism and type of interaction between CBD and tramadol below. One of the worst feelings for a dog owner is knowing that your four-legged best friend is in pain, but not being quite sure on what to exactly do for them. Whether your pup is experiencing pain from aging bones and joints or recovering from surgery, your vet will very likely prescribe conventional pain medication. Th

All About Tramadol for Dogs Including Alternatives

Pain treatment is an unfortunate reality many dog owners must face at some point. It’s sad, but it’s also scary. If your dog is already sick and suffering, you feel everything you do for them is of the utmost importance. Is the treatment enough? Will it make them worse somehow?

Is it safe? Whether your dog has cancer or arthritis, has been injured, or has just had surgery, your vet is likely to prescribe anti inflammatory drugs. You want to know everything there is to know about it and if there are other alternatives , should you decide you don’t like the idea of giving a particular medication to your pet.

Why Vets Choose Tramadol for Dogs

Tramadol hydrochloride is a powerful, synthetic opioid painkiller that can be used for treating mild to moderate pain alone, and severe pain in conjunction with other medications. Veterinarians choose to prescribe it for both acute and chronic pain conditions, meaning dogs can take it both short and long term.

As an opioid, Tramadol for dogs does more than just treat pain. It also impacts mood and may be prescribed for anxiety.

Tramadol is one of the most popular pain killers prescribed for dogs because the side effects from Tramadol are usually mild and veterinarians usually hold that the risk of addiction is less than with comparable medications, though there is some debate on how true that is. When used properly, Tramadol can be a safe and effective way to manage acute pain in dogs.

For chronic pain, it may take weeks for the effects to become noticeable. For this reason, and if Tramadol dosages are not enough to provide therapeutic relief for your dog, other painkillers may be prescribed along with it.

What does Tramadol do for pain in dogs?

Tramadol is an opioid analgesic used to treat moderate to severe pain in dogs. Tramadol can be administered as a tablet, chewable or liquid oral solution and should not be given with anything that contains milk protein because drug interactions can cause an allergic reaction.

Tramadol is commonly prescribed in veterinary medicine to help relieve pain in their patients’ best friends – our canine companions! Interestingly enough, this medication also has some side effects on people called “serotonin syndrome.” This means you may experience hallucinations if tramadol interacts with other medications your taking like antidepressants or blood pressure pills which are both designed to increase serotonin levels naturally.

Tramadol is a prescription medication used to treat pain. It’s often used post-operatively to help manage pain, and it can also be used to treat arthritis pain and other chronic conditions. Tramadol works by changing the way the brain responds to pain signals.

Tramadol is available in both oral and intravenous forms, but the intravenous tramadol form is generally only used in hospital settings. Oral tramadol can be given with or without food, but if your dog is vomiting or doesn’t seem to tolerate the medication well, your veterinarian may prescribe the intravenous form.

How Tramadol Works

Tramadol is an opioid working similarly to how you generally perceive such medications. It impacts the chemicals and receptors in the brain that influence the perception of happiness and pain, specifically serotonin and norepinephrine. Like many other medications, the exact mechanisms that make it work are unknown.

Tramadol Dosage for Dogs

Tramadol is a human medication as well as a dog medication. Dogs, of course, need a different dosage because their bodies are different from ours. You could give your dog your own Tramadol prescription medications if you needed to, but it should be done under the guidance of your licensed veterinarian.

The correct Tramadol dose is determined by many factors, including the the dog’s body weight and state of health of the dog, as well as the cause and severity of the pain.

The most widely accepted advice on Tramadol dosage for dogs is that it should be based from the 1 mg per 1 pound of dog model and varied according to the dog’s health and the pain management level as described above.

It will usually be given 8 to 12 hours apart or a bit more frequently for cancer pain. If your veterinarian prescribed tramadol in a very different amount from this, you should ask them why to ensure your dog is not being under or over treated.

As any pet parent knows, watching your dog suffer from pain can be heartbreaking. You just want to do whatever you can to help them feel better. When your dog is dealing with chronic osteoarthritis, you might wonder if tramadol is the right option for pain relief.

Unfortunately, a recent study has shown that tramadol may not be as effective as we thought for treating pain and joint dysfunction in dogs with chronic osteoarthritis. While it’s still important to talk to your veterinarian about whether or not to prescribe tramadol for your dog, this study provides important information that pet parents should be aware of.

You can’t crush Tramadol, it makes it not work correctly. If you find you can’t give Tramadol to your dog any other way, you should ask your vet for another medication.

Tramadol is a pain reliever that can be given with or without food, depending on what works best for your dog. Some dog parents find that their dogs do better when they take tramadol with food, while others find that it doesn’t make a difference. If your dog vomits when taking tramadol on an empty stomach, you may need to give future doses with food or a treat.

Side Effects of Tramadol for Dogs

Your dog should tolerate Tramadol pretty well. Most do not experience troubling side effects because the vet carefully chooses the dose to prevent over-medicating the dog.

If they do have side effects from Tramadol, they could be:

  • sedation
  • nausea
  • vomiting
  • loss of appetite
  • constipation
  • diarrhea
  • dizziness
  • lack of coordination
  • anxiety
  • behavior changes
  • tremors

Should your dog experience negative side effects from taking Tramadol, discuss them with your veterinarian to ensure they are not getting too much medication or it simply isn’t working well for them. Something may need to be done about the dosage or the type of medication, or there could be a treatment for the side effect.

Concerns about Tramadol for Dogs

Tramadol Overdose in Dogs

Pet owners greatest concerns about Tramadol are overdose and addiction. A dog taking too much Tramadol could hurt themselves, become frighteningly sedated, or even die. The dog’s blood pressure, breathing, and slow heart rate are overdose symptoms of Tramadol.

If this situation becomes severe enough, it can lead to death. Thankfully, this is very rare. Should your dog show signs of Tramadol overdose, you should get them to a vet as soon as possible.

Tramadol Addiction in Dogs

Opioids make dogs feel euphoric, that super good feeling that makes humans get addicted to drugs. It is also way too easy for the dog’s body to become tolerant to a certain level of medication and require more medication to maintain the same effect.

If the dog improved a great deal on the drug and then that improvement seems to wane, it may seem logical to increase the dosage, but this can be the path to your dog taking too much Tramadol.

If the medication’s effectiveness wanes, it is usually more prudent to prescribe an additional treatment rather than up the dosage.

Even if the dog has never been given an excessive amount of Tramadol, they can suffer withdrawal when they stop taking it, or their dosage is lessened.

Any change in the amount of medication given to your dog should be discussed with the vet and tapered off slowly. Never, ever just stop giving your dog Tramadol.

Allergic Reactions to Tramadol in Dogs

It is possible for dogs to have an allergic reaction to Tramadol.

Consult your veterinarian immediately should your dog experience:

  • rashes
  • itching
  • a racing heartbeat
  • diarrhea
  • swelling
  • sneezing
  • coughing
  • hives
  • difficulty breathing

In fact, discuss any adverse reaction your dog has with your vet to be on the safe side. Even if a symptom is not a sign of an allergic reaction, if it is negatively impacting your dog, something might be done to alleviate the problem.

See also  CBD Oil Gastroparesis

Tramadol Warnings Before Use

Tramadol should not be given to a dog who:

  • is taking MAOIs
  • is taking SSRIs, anti-depressants
  • is taking Digoxin, Quinidine, or Warfarin
  • has seizures now or in the past
  • is pregnant or nursing
  • has liver disease
  • has kidney disease
  • dogs who have had trouble with Tramadol or other opioids in the past

Tell your veterinarian about any drugs, even holistic treatments, your dog is already taking. This drug may exacerbate the side effects of drugs it is already on. Also, discuss any health conditions with your vet.

Alternatives to Tramadol for Dogs

You may have decided you are not comfortable with your dog taking Tramadol. Or you may be okay with them taking it, but you’d like to know what other options are out there in case the Tramadol stops working or doesn’t work well enough.

CBD Oil as a Substitute

CBD oil is an excellent replacement for an opioid medication such as Tramadol because it provides the same type of relief in a safer, non-addictive, and natural form.

CBD stands for cannabidiol, and you guessed it, it comes from marijuana and hemp. This doesn’t mean your dog will get high. CBD oil sold for pets is made from hemp, which is naturally extremely low in the chemical, THC, that could make your dog high.

Of course, if your dog gets a large enough dose of Tramadol, they will get high from that.

Cannabidiol acts on chemicals and receptors in the brain similarly to the way that Tramadol works. Dogs have an endocannabinoid system that produces its own cannabinoids and need a certain balance of them to function well.

Much of the components of this system are the same as those that opioids and SSRIs treat.

CBD oil helps dogs by:

  • alleviating pain
  • improving mood
  • decreasing anxiety
  • decreasing inflammation
  • providing additional nutrition
  • improving stomach problems like nausea or loss of appetite
  • giving them more energy

Scientists prove more ways all the time that CBD oil helps dogs, and veterinarians are helping devise CBD oil products. It is a valid, scientifically-backed method of treating and/or managing many conditions.

Your vet should be willing and able to assist you in using this treatment.

Why CBD Oil is Better Than Tramadol

CBD is all-natural and non-addictive. In fact, it is virtually impossible to give your dog too much CBD oil as all it can do is give them a sedative effect. There is no evidence of a dog having a life-threatening sedative effect from CBD oil.

Tramadol does nothing for inflammation, while CBD oil does. So, if your dog’s pain is coming from inflammation, CBD oil can both help treat the pain and decrease the inflammation, rather than your dog taking Tramadol and another medication to treat the inflammation.

CBD oil shows promise as a cancer killer. If your dog has cancer and that is why they need Tramadol, then CBD oil could both help manage to alleviate their pain and potentially treat their cancer.

This has not been definitively proven yet, but scientists have gotten exciting results and are continuing to test.

You might want to use CBD oil in conjunction with current cancer treatments or as the main treatment should your dog have cancer too advanced to be treated by conventional means.

Discuss CBD oil with your veterinarian as a potential substitute for or addition to Tramadol.

They can tell you the benefits and specific dosing for your dog, as well as how they expect it to interact with any treatments they may be offering.

CBD could be particularly helpful for dogs who can’t take Tramadol, are taking it and it is not effectively reducing their pain, or need the additional benefits CBD oil can provide.

How to Give Your Dog CBD Oil Instead of Tramadol

There is a huge range of products being made with CBD oil for dogs so you can give CBD oil to even the most finicky dogs.

You can find CBD oil in many forms your dog might like to take:

  • oil tinctures
  • oil sprays
  • capsules
  • treats
  • soft chews

Tinctures in droppers or pumps as well as sprays can be applied directly to the dog’s mouth or applied to their food.

This is the most effective means of delivering CBD oil to your dog as you have the most control of the amount they get, and it is the purest form, i.e. contains fewer ingredients.

Many tinctures and sprays contain flavorings to mask the taste of hemp because it can be a bit off-putting. You can pick which one you think your dog will most like.

Capsules are good for ensuring you are giving your dog an exact amount of CBD oil and masking the taste of the oil. Some dogs don’t like the hemp taste, even when it’s masked with other flavors.

If you’re adding CBD oil from a tincture to their food, you could also discover that they don’t eat all the food and then you aren’t sure how much CBD they ingested. A capsule can prevent that.

Treats and soft chews offer a fun way to get CBD oil into a dog who doesn’t want to take it in other forms.

A quality manufacturer of CBD oil treats and soft chews will ensure an exact, measured dosage of CBD oil in each treatment and keep ingredients as low as possible. They may have real meat in them and taste as good as their normal treats.

Dosages of CBD Oil for Dogs

The product you buy will tell you how much to give according to your dog’s weight. Often, when purchasing, you’ll need to choose an option based on the size of your dog. The dosage can be raised up or down as you deem is needed after trying it out on your dog.

It’s easy to adjust because there is so little risk that your dog will have an adverse reaction. If you are concerned about managing this yourself, you can ask your vet for advice.

Choosing A CBD Oil Product for Your Dog

Do read the ingredients list on any product you consider for your dog. There may be an alarming amount of ingredients, some may not be natural, and some are, sadly, not really safe.

Learn where the company making the product acquired or grew their hemp. Some companies are not honest and sell CBD oil made from poor-quality or fake hemp.

Check for lab results from third-party testing on the product you’re considering. This will help you ensure you are getting the amount of CBD oil the company promises.

And that there really is CBD oil in the product. It is possible to mistakenly purchase products claiming to contain CBD oil that have no actual CBD oil in them.

Most CBD oil companies boast that they sell natural products because their target market likes it, but you can also find organic hemp CBD oil products. Organic is best because you’re avoiding potentially harmful chemicals.

This would not normally be pesticides because hemp is naturally pest repellant, but the CBD oil manufacturer may use other chemicals or purchase ingredients that contain chemicals.

Look for a mention of the manufacturer using the CO2 extraction method as it is the safest and purest way of extracting CBD oil.

Full-Spectrum vs Isolate CBD Products

You may get confused by labels saying full-spectrum or CBD isolate. CBD isolate is just CBD oil as opposed to full-spectrum which is CBD oil with some other cannabinoids, phytonutrients, terpenes, and other nutrients dogs can get from the entire hemp plant.

Most people want full-spectrum CBD oil to gain a broader range of nutrients and cannabinoids. If you don’t want that, only wanting to administer CBD and the few ingredients in the form sold to your dog, then a CBD isolate is fine. You may discuss the benefits of full-spectrum CBD oil versus CBD isolate with your vet. The need varies depending on the ailment your dog is suffering from, nutrients they may need to gain from a supplement, and what simply works better for your dog.

Where to Find CBD Oil for Dogs

100% organic CBD products are exploding in popularity all over the internet, some great and most scary. You can start your journey into the world of pet CBD oil with Innovet Pet Products CBD Oil and Hemp Treats.

Our CBD oils are:
  • full-spectrum
  • extracted using the cold CO2 method
  • sourced from Oregon, Germany, and the U.K.
  • legal in all 50 states
  • THC-free
  • third-party lab tested with results available on the website
  • Current products include tinctures, capsules, treats, and soft chews. We do not have any CBD isolate products at this time.
See also  Whole Leaf CBD Oil

Do ask us about creating products specifically for your pet. Should you want CBD isolate, feel that one of our products could be made better, or have a pet ailment that there isn’t a product to treat, or treat effectively, contact us to see if we can’t create a solution specifically for your pet. We’re in the business of treating the trickiest pet problems. You can also purchase supplies for helping you administer medication to your pet from us.

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I was very impressed with your site. The language was quite understandable, and easy to read. I have two German Shepherds around 7 years young. One has cancer growing on his heart that is slow growing, and the other has hip dysplasia, bone on bone. They are both bright and playful, just not ready to lose them until they show me it’s time. My Vet is very good I think, and she has them both on Tramadol, close to same weight and age. I am having alot of trouble getting them to take the pills. I have tried Pill Pockets; hamburger, other soft food, cottage cheese, mac and cheese. And then I read at your site to say away from milk products. Thank you for the proper information. If you have any suggestions to help them, please feel free.. And again thank you for the quality information.

**Review Disclaimer: In accordance with FDA/FTC regulations regarding product/advertising claims and to ensure full transparency to the public testimonials displayed on are given verbatim as we do not have the ability to change any reviews made by customers. Testimonials appearing on this site are actually received online and are processed through YOTPO – the leading independent review auditor. These are individual experiences of real-life people who have administered our products to their pets. However, they are individual results and results do vary. The testimonials are not necessarily representative of all of those who will use our products and/or services. is not a forum for testimonials, however, we do provide testimonials as a means for customers to share their experiences with each other. Innovet Pet does not necessarily share the opinions, views, or commentary of any testimonials on this site specifically because such views are strictly the views of the reviewer.
Additionally, these testimonials are not intended to make or imply claims that these products can be used to diagnose, treat, cure, mitigate, or prevent any disease. Statements within these testimonials have not been clinically reviewed or evaluated by the FDA. Please consult your veterinarian about potential interactions or other possible complications before using any product. The information on our website is intended to inform the public in the most honest and transparent way possible.

Does CBD Interact With Tramadol (Ultram)?

Information on risks & possible interactions between CBD & tramadol.

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One of the most common uses of CBD is for managing chronic pain. Currently, the most common prescription painkillers are opioid drugs such as tramadol (Ultram).

Is it safe to take CBD with tramadol? What are the potential risks of taking both together?

Table of Contents

Does CBD Interact With Tramadol (Ultram)?

CBD and tramadol (Ultram) may interact in three different ways — each one has the potential to cause side effects.

Be very cautious when taking CBD with tramadol, and always speak to your doctor before taking both at the same time.

Separating the dose of CBD and tramadol 2 hours apart may reduce the chances of side effects.

1. Agonistic Interaction

Tramadol and opioid analgesics cross the blood-brain barrier to produce their benefits. To cross the blood-brain barrier, drugs like tramadol require the help of P-glycoprotein, which is inhibited by CBD, hence reducing the clearance of the drug from the brain.

CBD also inhibits the enzymes required for metabolism and, consequentially, excretion of tramadol from the body resulting in prolonged presence of the drug in the system.

This increases the time the drug spends in the system, allowing it to have prolonged effects, resulting in an agonistic interaction between CBD and tramadol.

2. Antagonistic Interaction

CBD, in high doses, is known to inhibit the analgesic activities of tramadol or reduce them, making the drug inefficient. The exact mechanism for CBD’s action is not yet known, but it is referred to as an antagonistic interaction between CBD and tramadol.

3. Metabolic Inhibition

Tramadol (Ultram) and CBD require enzymes for their metabolism; they share some of these enzymes, creating competition between the agents. This is referred to as metabolic competition and is one type of interaction between CBD and tramadol.

Other Names for Tramadol

Tramadol is sold under many different names. All share the same risk and potential interactions.

Other names for tramadol include:

Similar Medications: CBD & Opiates

Tramadol (Ultram) is classified as an opiate medication. CBD and opiates all share similar risks for interaction and side effects.

Here’s a list of similar medications that share a similar level of risk when combined with CBD:

  • Buprenorphine (Cizdol & Brixadi)
  • Codeine
  • Pethidine (Meperidine & Demerol)
  • Fentanyl (Abstral & Actiq)
  • Hydrocodone (Hysingla ER, Zohydro ER & Hycodan)
  • Hydromorphone (Dilaudid)
  • Methadone (Methadose & Dolophine)
  • Morphine (Kadian & Roxanol)
  • Oxycodone (Percodan, Endodan, Roxiprin, Percocet, Endocet, Roxicet & OxyContin)

Is It Safe to Take CBD & Tramadol (Ultram) Together?

CBD interacts with tramadol (Ultram), producing significant clinical symptoms mainly in respiratory depression and coma, which can be fatal if not appropriately treated and managed. Moreover, CBD in high doses inhibits the analgesic effects of tramadol, hence reducing the positive effects of the drug while increasing the negative effects.

Given the risk of severe side-effects along with CBD’s ability to decrease the effects of tramadol, it is not recommended to take CBD and tramadol together.

Is CBD a Viable Alternative to Tramadol (Ultram)?

CBD initially gained traction for its analgesic and anti-inflammatory properties, which help alleviate different types of pain in patients [1]. Tramadol (Ultram) and CBD are potent pain-relieving agents; however, the former tends to cause dependence and addiction and requires a prescription. On the other hand, CBD can be used freely without any risk of addiction or habit formation.

Moreover, tramadol and other opioid analgesics have a higher risk of patient overdoses than CBD or even average pain killers. As CBD decreases the risk of fatal overdoses and provides similar benefits as opioid analgesics, it may be a viable alternative for these medications, including tramadol [2].

While anecdotal evidence points to the benefits of CBD over tramadol, further scientific research and evidence are required for CBD to become the standard medical analgesic, replacing opioid analgesics like tramadol.

What Is Tramadol (Ultram)?

Tramadol is an opioid analgesic commonly sold under the brand name Ultram and used to manage moderate to severe pain, bringing relief within an hour of oral ingestion of the pill. Tramadol is commonly prescribed for pain, over other opioid analgesics, because of its reduced ability to produce side effects such as dependence and addiction. Tramadol is addictive, however, and special care should be taken when prescribing this medication to high-risk populations.

Tramadol is metabolized in the liver into desmetramadol, an opioid with a higher affinity for opioid receptors. It helps treat pain disorders such as fibromyalgia and trigeminal neuralgia. The FDA has not approved the use of this medication in treating these pain disorders but rather only for the treatment of acute and chronic pain. The FDA has approved the use of tramadol IV for the management of pain, while the National Health Service (NHS) has approved tramadol as a secondary drug for the treatment of pain disorders.

Tramadol is sold under different brand names such as Ultram, Zytram, Qdolo, Ryzolt, and ConZip, with Ultram being the most readily available and commonly used brand.

The drug becomes effective within an hour of ingesting, but it takes around 2 hours to 4 hours for the medication levels to peak in the body. It belongs to two different classes of medications, namely, opioid analgesics and Serotonin Norepinephrine Reuptake Inhibitors (SNRI), with the former being the more commonly known class.

Compared to other opioid painkillers such as morphine and codeine, tramadol is not that effective, but it is still used because it’s less addictive.

Tramadol is metabolized in the liver using demethylation and glucuronidation via the enzymes CYP2D6 and CYP3A4. Its elimination half-life and duration of action is approximately 6 hours, with most of the drug excreted in the urine.

Tramadol interacts with CBD, another potent analgesic agent, to produce majorly significant clinical symptoms and side effects that have the potential to be fatal without appropriate medical attention. CBD has both an agonistic and antagonistic effect on tramadol, depending on its dosage.

Tramadol Specs:

Drug Name Tramadol
Trade Name Ultram, Zytram, Qdolo, Ryzolt, ConZip
Classification Opioid Analgesic
CYP Metabolism Liver (CYP2D6 and CYP3A4)
Interaction with CBD Antagonistic (Decreased effects) of high dose Tramadol Agonistic (Increased Effects)
Risk of Interaction Major
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How Does Tramadol (Ultram) Work?

Tramadol (Ultram) is an opioid agonist that targets the noradrenergic system, serotonergic system, and opioid system.

Tramadol affects the following receptors and processes in the body to produce its analgesic effects:

  1. Mu Opioid Receptor or MOR, as an agonist, followed by other opioid receptors such as DOR and KOR. Tramadol has the highest affinity for MOR amongst the three opioid receptors in the body.
  2. Serotonin and norepinephrine reuptake from the synapses as tramadol is an active inhibitor of these reuptakes, hence belonging to the SNRI class of antidepressants.
  3. M1 and M3 muscarinic receptors in the body, as an antagonist.
  4. Serotonin 2C receptor, as an antagonist.
  5. Alpha 7 nicotinic acetylcholine receptor, also as an antagonist.

The main benefit of tramadol is pain management, and it does so by binding to the MOR using its active metabolite, desmetramadol. This metabolite is formed as a result of the metabolism of the drug in the liver.

Side Effects of Tramadol (Ultram)

Tramadol (Ultram) is an opioid analgesic with a few common side effects associated with its use, such as:

  • Abdominal Pain
  • Anxiety
  • Constipation
  • Dizziness
  • Drowsiness
  • Dry mouth
  • Flatulence
  • Headache
  • Irritation and Agitation
  • Itching
  • Menopausal symptoms
  • Nausea
  • Rash
  • Sleep Disorders
  • Urinary frequency
  • Urinary retention
  • Vertigo
  • Visual disturbance
  • Vomiting
  • Weight loss

Tramadol also has some rare side effects associated with its use that are also higher in severity:

  • Bradycardia
  • Dyspnoea
  • Epileptiform convulsions
  • Gastrointestinal bleeding
  • Hallucinations
  • Heart Attack
  • Hepatitis
  • Hypertension
  • Kidney damage presenting with Proteinuria
  • Liver failure
  • Migraine
  • Pulmonary edema
  • Pulmonary embolism
  • Respiratory depression
  • Stevens-Johnson syndrome
  • Tinnitus

Tramadol can also produce dependence and addiction, two of the most severe and common side effects of the medication. It is essential to take this medication only when prescribed by a medical professional and follow precautions carefully. The side effects mentioned above can increase in intensity and severity if tramadol is taken with CBD, a potent pain-relieving cannabinoid.

Types of Drug Interactions With CBD

CBD has gained traction recently and has been made widely available for its several benefits. However, it can interact with other medications and drugs, resulting in severe side effects and complications.

The interactions between the drugs and CBD can be of low clinical significance, moderate clinical significance, or major clinical significance. In case of low interactions, CBD can be used alongside the drug, whereas for moderate interactions, the use of CBD with the drug should be avoided unless medically necessary. If CBD has significant interaction with a drug, then the two agents should not be taken together.

Based on the effect of CBD on the medication and its properties, drug interactions with CBD are classified as:

1. Agonistic Interaction

CBD increases the effects or the time the medications spend in the system by inhibiting the clearance of the drug or working synergistically with the drug. Although the net effect is increased effects of the medication, it does not produce positive results but rather unfavorable results.

2. Antagonistic Interaction

CBD inhibits the activity of the drug or hastens the clearance of the drug, decreasing the overall positive effect of the medication, hence, producing an antagonistic interaction.

3. Metabolic Inhibition

CBD competes for the drug for the enzymes that both agents need for their own metabolism.

Key Takeaways: Is CBD Safe to Take With Tramadol (Ultram)?

Tramadol (Ultram) is an opioid analgesic with a weak inhibitory effect on serotonin reuptake and norepinephrine reuptake. It has one-tenth of morphine’s analgesic properties and is often used as a secondary treatment for pain disorders or as a primary treatment of acute and chronic pain.

It is widely used because it’s less likely to produce dependence and addiction. CBD also has potent analgesic properties. However, it’s not recommended for them to be used together as CBD, in high doses, inhibits the action of tramadol and the enzymes necessary for metabolism and clearance of the drug, resulting in prolonged effects of tramadol on the system.

Prolonged effects increase the risk and severity of the several side effects of tramadol, most important of which are respiratory depression and coma.

Tramadol And CBD Oil Interaction In Dogs

One of the worst feelings for a dog owner is knowing that your four-legged best friend is in pain, but not being quite sure on what to exactly do for them. Whether your pup is experiencing pain from aging bones and joints or recovering from surgery, your vet will very likely prescribe conventional pain medication.

Things may get worrisome a bit below. Here’s a quick glance into potential adverse reactions associated with nearly every medication could terrify most dog owners. From kidney damage to liver failure to death, the number of things that could potentially go worrying is scary. Yet, what can you do? You don’t want your doggo to be in pain, but is there another way?

In today’s article, we’ll cover the do’s and don’ts of commonly prescribed pain medication called Tramadol. It is recommended to only use this medication based on the guidance and advice of your vet, and it is essential for you to also know the associated risks of this medication.

Additionally, we will cover holistic alternatives that prove to be effective and safe.

Tramadol for Dogs

Tramadol is a prescribed medication that many vets recommend for your dog’s pain management. You might recognize the name, as it’s also prescribed by many physicians to treat pain in us humans.

In fact, tramadol is one of the few human painkillers that vets deem safe to give to pups, under vet supervision of course! A tramadol prescription however, should never be shared between owners and pets.

Each case is different and should be monitored closely by your vet (in your case, your physician, depending on who prescribed you the drug).

How Tramadol Works

Tramadol is a member of the opioid fam. Its job is to inhibit the reuptake of serotonin and norepinephrine in the brain. This increases levels of these substances in the bloodstream and alters pain perception in both humans and dogs.

Furthermore, the increased levels of serotonin and norepinephrine in the bloodstream helps to initiate sensations of wellbeing and euphoria, allowing your pup to be pain-free, mentally calm, and physically relaxed.

As you’ve heard, opioids can be addictive in humans, the drugs don’t affect our dogs in the same, dangerous manner though. Some dogs, however, may experience withdrawal symptoms once treatment has stopped.

What is Tramadol Used For

Tramadol is primarily used to manage general, acute, and chronic pain in doggos. However, in this mini section, we’ll break down specific reasons why tramadol may be prescribed for your dog.

1) Osteoarthritis

One of the main reasons for tramadol prescriptions is the treatment of the osteoarthritic signs in dogs. It is important to note that tramadol alleviates signs and is not at all a cure for underlying causes of the condition.

As your dog begins to age, their bones and joints begin to wear and tare from years of constant use.

This wear and tare creates inflammation and pain that can cause your four-legged pooch to become lethargic, depressed, and sometimes even shy away from physical attention for fear of being handled or touched in a way that may result in more pain.

In these cases, your vet may prescribe tramadol for your pup. Help is on the way doggo!

2) Treating Postoperative Pain

Vets prescribe tramadol to manage pain resulting from recent surgeries too. It is important to note if you are using tramadol to manage post-op pain, making sure to keep a close eye on your dog, making sure he or she isn’t overexerting themselves.

The medication will help relieve their pain, which can lead to an increase in their activity, even possibly leading to insufficient rest, and unfortunately, an inability to fully heal from the recent surgery.

3) Managing Cancer

Your vet may prescribe tramadol to ease symptoms associated with cancer in addition to traditional cancer treatment.

If your pup is fighting cancer, the last thing you want is for them to be in even more pain than need be. Tramadol may be an effective way to reduce their distress and even increase their serotonin levels.

4) Treating Hip Dysplasia

Tramadol is also prescribed to help pain and discomfort associated with hip dysplasia and other joint disorders.

Again, tramadol doesn’t work to cure the foundational cause of these disorders, but merely helping manage the associated pain and discomfort your dog may be facing.

In addition, in less common situations, your vet may prescribe tramadol to relieve anxiety and coughing.

Potential Side Effects of Tramadol

Like all traditional medications, tramadol can have its fair share of potential side effects. Studies have shown that most dogs tend to tolerate tramadol well.

However, the following side effects may still occur in dogs with varying degrees of pain: